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ea0093oc10 | Oral communication 2: Neuroendocrinology | EYES2023

Effects of glucagon-like peptide-1 receptor agonists on copeptin in healthy volunteers and patients with primary polydipsia

Leibnitz Svenja , Christ-Crain Mirjam , Winzeler Bettina

Background: Today, GLP-1 receptor agonists have great clinical importance in the treatment of type 2 diabetes and obesity. Furthermore, GLP-1 seems to play a significant role in sodium and water homeostasis. Recent findings investigating long-term effects of treatment with GLP-1 receptor agonists showed a reduction of fluid intake irrespective of food consumption. To our knowledge, data regarding physiological mechanisms that could explain these observations are inconclusive. ...

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ea0099oc5.1 | Oral Communications 5: Pituitary and Neuroendocrinology | Part I | ECE2024

Effects of Glucagon-like Peptide-1 Receptor Agonists on Copeptin in healthy volunteers and patients with primary polydipsia-A secondary analysis of the randomized, double-blind, placebo-controlled, crossover GOLD & GATE trials

Leibnitz Svenja , Christ-Crain Mirjam , Winzeler Bettina

Background/Introduction: Today, GLP-1 receptor agonists have great clinical importance in the treatment of type 2 diabetes and obesity. Beside their known mechanisms to lower blood sugar and enhance satiety signals, GLP-1 also seems to play a significant role in sodium and water balance. This can be supported by the finding of GLP-1 receptor expression in various locations of the kidney, the enteric system and key brain structures. Recent findings investigating long-term effec...

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Endocrine Abstracts

Effects of glucagon-like peptide-1 receptor agonists on copeptin in healthy volunteers and patients with primary polydipsia

Effects of Glucagon-like Peptide-1 Receptor Agonists on Copeptin in healthy volunteers and patients with primary polydipsia-A secondary analysis of the randomized, double-blind, placebo-controlled, crossover GOLD & GATE trials

BiosciAbstracts